Career Profile

At Rowan University, I currently lead and manage a research team consisting of eight undergraduates, and two graduate students. The undergraduate team is currently working on AI applications in support of ICU clinicians by examining ensemble and feature selection methods to find the optimal mortality prediction model. The graduate students are focused on explainable AI and how we can evaluate the performance of these methods across different domains. I deployed the mortality prediction model in 2021 via web app and am working with ICU clinicians to continually update the app to support their needs. The focus of my research is on the intersection of explainable AI and Bayesian neural networks. In addition to my research, I work full time as a Advanced Machine Learning Engineer at CACI where I am fusing audio, video and text data to predict key endpoints on a variety of problems.

Publications

  • Deployment of a Robust and Explainable Mortality Prediction Model: The COVID-19 Pandemic and Beyond
  • Jacob R. Epifano, Stephen Glass, Ravi P. Ramachandran, Sharad Patel, Aaron J. Masino, Ghulam Rasool
    Submitted: Artificial Intelligence in Medicine (Elsevier), 2023
  • Revisiting the Fragility of Influence Functions
  • Jacob R. Epifano, Ravi P. Ramachandran, Aaron J. Masino, Ghulam Rasool
    Published: Neural Networks (Elsevier), 2023
  • Video Quality Estimation with RAPIQUE-Python -- A Tutorial
  • Jacob R. Epifano, Aaron J. Masino, Rich Christe
    Submitted: IEEE Transactions on Image Processing, 2023
  • A Comparison of Feature Selection Techniques for First-day Mortality Prediction in the ICU
  • Jacob R. Epifano, Alison Silvestri, Aakash Tripathi, Alexander Yu, Ghulam Rasool and Ravi P. Ramachandran
    Published: IEEE International Symposium on Circuits & Systems (ISCAS), 2023
  • Performance Evaluation of Combination Methods of Saliency Mapping Algorithms
  • Ian E. Nielsen, Jacob R. Epifano, Ghulam Rasool, Nidhal C. Bouaynaya and Ravi P. Ramachandran
    Submitted: International Symposium on Circuits and Systems (ISCAS), 2021
  • Towards an Explainable Mortality Prediction Tool
  • Jacob R. Epifano, Ravi P. Ramachandran, Sharad Patel, Ghulam Rasool
    Published: Machine Learning for Signal Processing (MLSP), 2020
  • Machine Learning Analysis of Digital Clock Drawing Test Performance for Differential Classification of Mild Cognitive Impairment Subtypes Versus Alzheimer’s Disease
  • Russell Binaco*, Nicholas Calzaretto*, Jacob Epifano*, Sean McGuire*, Muhammad Umer, Sheina Emrani, Victor Wasserman, David J Libon, Robi Polikar
    Published: Journal of the International Neuropsychological Society (JINS), 2020

    Skills & Proficiency

    Python - Numpy, Pandas, Scikit-learn
    Machine learning - Pytorch, HuggingFace, LangChain, Tensorflow, Keras, Explainable AI (XAI), Bayesian Neural Networks, Healthcare, Bioinformatics, Feature Selection, Image Processing
    Platforms - Git, HPC, GCP, AWS, Azure
    Digital Signal Processing
    Agile/Scrum
    MATLAB
    LaTeX

    Experiences

    Visiting Machine Learning Scientist

    February 2024 - Present
    Moffitt Cancer Center, Tampa FL
    • Wrote Retrieval-Augmented Generation (RAG) Tutorial Paper
    • Designed and implemented Moffitt Electronic Health Record Foundation Model to extract and abstract a set of pre-defined descriptive fields and endpoints from Moffitt EHR

    Advanced Machine Learning Engineer

    May 2023 - Present
    CACI, Florham Park NJ
    • Designed and implemented LLM-based RAG pipeline for sensitive document sanitation
    • Designed and implemented VAE to predict anomalies in network traffic
    • Designed and implemented feature extraction pipeline to perform Network Address Translation (NAT) detection on real time network traffic
    • Collaborated on research studies on deepfake and AI generated text detection

    Senior Data Scientist

    November 2021 - May 2023
    AiCure, New York NY
    • Implemented cross-attention transformer approach to fuse audio, video and text data to predict clinical endpoints.
    • Designed and implemented flexible multi-model feature extraction pipeline using AWS Batch to extract Digital Biomarkers from audio and video data.
    • Designed and implemented automated video quality assessment pipeline for data filtering and cleaning prior to use in downstream prediction models.
    • Collaborated on research studies with industry partners such as University of Rochester, Bristol Myers Squibb, Boehringer Ingelheim, and others.

    DSP/ML Consultant

    March 2021 - July 2022
    RTM Vital Signs, Philadelphia PA
    • Designed and implemented signal processing pipeline for auditory breathing data
    • Designed and implemented feature extraction and model selection pipelines to convert audio to tidal volume and respiratory rate
    • Implemented hyperparameter optimization via Bayesian search

    Student Informatics Assistant II

    November 2018 - June 2021
    Children's Hospital of Philadelphia, Philadelphia PA
    • Implemented Influence functions in PyTorch
    • Implemented and tested machine learning pipeline for detecting Acute Respiratory Distress (ARD) events in children. Paper has been submitted to Anesthesiology (ASA)
    • Designed, implemented and tested early warning system for mortality in ICU based on vital signs
    • Served as a consultant to co-workers on deep learning technologies such as PyTorch and PyTorch-lightning

    Radar Systems Engineer

    May 2018 - November 2018
    Lockheed Martin, Moorestown NJ
    • Researched and tested various deep learning solutions for Radar Discrimination
    • Presented findings to colleagues from MIT, SEG, and APL
    • Purchased hardware for future machine learning efforts

    Quality Management Intern

    June 2017 - September 2017
    Naval Surface Warfare Center, Philadelphia PA
    • Updated Quality Management System and briefed NSWCPD Commanding Officer and Technical Director
    • Worked with the Chief Engineer on the standard operating procedure for Risk Management at NSWCPD
    • Designed MS Access-SQL Database for metric tracking

    Projects

    Deployment of an ICU Mortality Prediction Model - ML backend for my mortality prediction web app. This model has been trained to predict all-cause mortality based on first-day lab values. The model achieves state of the art performance over traditional mortality scores such as APACHE and SAPS. The novelty of the method is in its explanation and uncertainty quantification via influence functions and Bayesian inference.
    Influence Pytorch - Extension of influence function implementation for PyTorch. To support my models, a PyTorch compatible implementation of influence functions was needed. This implementation includes end-to-end gradients, enabling efficient computation of feature attribution.
    Reinforcement Learning - Implementation of Monte Carlo methods to find the optimal blackjack policy. This method achieves the theoretical maximum win-rate without card counting.
    Machine Learning - Implementation of classical machine learning methods such as Linear/Logistic Regression, SVM, MLP, etc